To get a first hand understanding of the impact of AI on the software development lifecycle (SDLC), I decided to run an experiment. I wanted to try and write a reasonably complex system from scratch using AI. I didn’t want a “Hello World” or another “To Do” app; I wanted something realistic, something that could be used at scale like we’d build in the enterprise world. The result is Under The Hedge—a fun project blending my passion for […]

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arXiv:2602.09246v1 Announce Type: new Abstract: The integration of Artificial Intelligence (AI) into Higher Education Institutions (HEIs) in Ecuador is not a technological option but a strategic imperative to prevent institutional obsolescence and academic irrelevance in Latin America. This paper presents the IA593 Framework, a governance, ethics, and operational model designed for the Universidad Nacional de Loja (UNL) and scalable as a reference for the Ecuadorian higher education system. The current context reveals a critical urgency: the Latin American […]

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Everyone talks about LLMs—but today’s AI ecosystem is far bigger than just language models. Behind the scenes, a whole family of specialized architectures is quietly transforming how machines see, plan, act, segment, represent concepts, and even run efficiently on small devices. Each of these models solves a different part of the intelligence puzzle, and together they’re shaping the next generation of AI systems. In this article, we’ll explore the five major players: Large Language Models (LLMs), Vision-Language Models […]

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arXiv:2506.22621v3 Announce Type: replace-cross Abstract: Simulation-based problems involving mixed-variable inputs frequently feature domains that are hierarchical, conditional, heterogeneous, or tree-structured. These characteristics pose challenges for data representation, modeling, and optimization. This paper reviews extensive literature on these structured input spaces and proposes a unified framework that generalizes existing approaches. In this framework, input variables may be continuous, integer, or categorical. A variable is described as meta if its value governs the presence of other decreed variables, enabling the […]

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arXiv:2403.15711v2 Announce Type: replace-cross Abstract: Causal representation learning (CRL) offers the promise of uncovering the underlying causal model by which observed data was generated, but the practical applicability of existing methods remains limited by the strong assumptions required for identifiability and by challenges in applying them to real-world settings. Most current approaches are applicable only to relatively restrictive model classes, such as linear or polynomial models, which limits their flexibility and robustness in practice. One promising approach to […]

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Parameter estimation for biochemical reaction networks is computationally demanding, especially for systems with oscillatory nonlinear dynamics, where standard iterative optimization strategies, including genetic algorithms, often struggle with prohibitive computational costs. We introduce an efficient parameter estimation framework that combines a real-coded genetic algorithm with a novel adaptive simulation termination strategy. This strategy defines a time-dependent termination boundary based on population quantiles, which is permissive during early transients and becomes progressively stricter as simulations advance, explicitly accounting for the […]

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Diffusion models generate samples through an iterative denoising process, guided by a neural network. While training the denoiser on real-world data is computationally demanding, the sampling procedure itself is more flexible. This adaptability serves as a key lever in practice, enabling improvements in both the quality of generated samples and the efficiency of the sampling process. In this work, we introduce an inverse reinforcement learning framework for learning sampling strategies without retraining the denoiser. We formulate the diffusion […]

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arXiv:2511.08855v2 Announce Type: replace-cross Abstract: Detecting chemical modifications on RNA molecules remains a key challenge in epitranscriptomics. Traditional reverse transcription-based sequencing methods introduce enzyme- and sequence-dependent biases and fragment RNA molecules, confounding the accurate mapping of modifications across the transcriptome. Nanopore direct RNA sequencing offers a powerful alternative by preserving native RNA molecules, enabling the detection of modifications at single-molecule resolution. However, current computational tools can identify only a limited subset of modification types within well-characterized sequence contexts […]

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A/B testing has become a gold standard for modern technological companies to conduct policy evaluation. Yet, its application to time series experiments, where policies are sequentially assigned over time, remains challenging. Existing designs suffer from two limitations: (i) they do not fully leverage the entire history for treatment allocation; (ii) they rely on strong assumptions to approximate the objective function (e.g., the mean squared error of the estimated treatment effect) for optimizing the design. We first establish an […]

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